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Browse articles and news about science, industry and the PipeBio platform.
IgLM is a generative antibody-specific language model for generating, infilling and diversifying antibody sequences
PipeBio has been acquired by Benchling! Read more about our shared vision to support future biologics discovery.
Camelids can produce HCAbs, which lack the CH1 domain, do not pair with light chains and show great promise in medicine and diagnostics.
Non-canonical cysteines form diverse disulfide bonds, shape conformational antibody diversity and antigen-binding sites, modulate effector function.
While the core differences between textual and protein sequences present a challenge, PLMs have proven very valuable to learn the underlying patterns.
Structural insights on antibody-effector interfaces enable Fc engineering to optimize therapeutic efficacy by tuning binding and effector functions.
The role of protein aggregation in biologics development, mitigating efficacy, product quality, and patient safety risks caused by protein aggregation
Combining single cell heavy and light chain NGS sequences with functional assays to accelerate decision making toward promising leads
The challenges of predicting antibody structure and assessing antibody developability in silico
Antibody discovery and engineering meetings we are looking forward to in 2024
An overview of next generation techniques for vaccine development, from immune monitoring to in-depth profiling of adaptive immune repertoires
Quantifying, evaluating and predicting antibody developability parameters
How combining public and proprietary data can help accelerate antibody discovery and development
Techniques for retaining native pairing of antibody heavy (VH) and light (VL) chains with NGS sequencing
How to use UMIs for error correction and accurate characterization of immune cells with NGS
From in vivo and in vitro to in silico design of antibody libraries for optimal developability and biophysical properties
Fall is a busy time for us, but we always look forward to seeing familiar faces at antibody conferences
The PipeBio team comes from a variety of different backgrounds, the passion for science uniting everyone
In this article we review computational methods for antibody structure and aggregation prediction and show example applications on PipeBio
A review of common cloning techniques, including restriction, PCR, gateway, Golden Gate and In-fusion cloning as well as Gibson Assembly
In this post we summarize in vitro display technologies including phage, yeast, mammalian, bacterial and ribosome display.
In silico and in vitro methods, data, and machine learning approaches in antibody discovery and engineering research.
PipeBio has rolled out many exciting features in 2022 and in this article we summarized a few of those
10x Genomics barcoding technology and analysis of single B cell barcoded repertoire sequences on the PipeBio platform
Choosing between standard antibody numbering schemes in antibody discovery and engineering
PipeBio supports Abalone Bio's antibody drug discovery efforts to target difficult membrane proteins
How to accurately annotate, define and characterize of antibody sequences – a crucial step in antibody drug discovery
In this article we write about re-sequencing synthesized sequences before amplification and subsequent functional analysis can be important
PipeBio bioinformatics cloud supports SSO and SCIM for enterprise-tier customers
Sanger sequencing remains an important tool for antibody discovery and engineering. Here we give an overview of Sanger tools and workflows on PipeBio.
PipeBio's customers are now routinely analyzing NGS sequences in the order of a couple of billion in a few days.
A key application of PHAGE-ATAC is rapid generation of antigen specific nanobodies in weeks. Here we cover the technologies incorporated in PHAGE-ATAC
Single cell sequencing technologies from 10x Genomics to the Beacon are a few among the effective tools for characterization of single immune cells
Since its conception in 1985, phage display has been widely used for identification and selection of peptides binding to a broad range of targets
A re-analysis of NGS data published by Hanke et al., where an immunized alpaca's antibodies were shown to neutralize the SARS-CoV-2 spike protein
We discuss the topic of p-values and how to draw statistically significant conclusions in bioinformatics analysis
This blog post highlights the synergy between label-free biosensors and the PipeBio cloud-based bioinformatics platform
We sat down with Reidar Poulsen of ProcessManager and learned about his job as an ISO consultant, what it means for a company to become ISO 27001 comp
Nanobodies are small in size and are able to reach difficult-to-drug targets. In this article we show how to identify enriched clones from biopanning
How to use known target-specific antibodies to find related clones from next-generation repertoire sequencing data
PipeBio allows you to maintain a reliable audit trail of your sequences and export files in multiple formats
LIBRA-seq is a high-throughput method to map individual antibodies to antigens
Here we describe Sanger as well as NGS sequencing by Illumina and PacBio, some of the most popular solutions in antibody discovery
Isogenica announces deployment of the PipeBio Bioinformatic Cloud
In this article we use PipeBio bioinformatics cloud to analyze non-antibody scaffolds, namely affibodies
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