Hit pick antibodies

Create phylogenetic trees, identify the most diverse sequences in your sample and hit-pick to express in vector and characterize your antibody sequences

Cross reactive antibody clones from 10x genomics BEAM experiment displayed on Phylogenetic tree dendrogram on PipeBio Bioinformatics antibody sequence analysis platform.

Identifying diverse antibody sequences, hit pick antibodies with good developability, less liabilities

Visualization and hit picking antibodies with functional assay data such as ELISA and FACS, SPR

Hit pick visually, based on diversity or apply powerful filters to find the best candidate sequences

  • Use PipeBio's diversity selection tool to extract the most diverse set of sequences
  • Define the clonotype based on different regions, such as CDRs, FRs or heavy and light chains (VH/VL)
  • Use functional data to overlay with antibody sequences to hit pick optimal candidates in your experiments
Table view of ELISA values highlighted with a conditional color scheme, amino acid barcharts of the CDR-H3 region and diversity scores for the antibody heavy chain sequences in the sample

Create phylogenetic trees and visualize your antibodies

  • Visualize your antibodies with dendrograms
  • Overlay ELISA, SPR, antigen specificity or other data from functional assays in interactive charts
  • Customize your charts and share with colleagues or export for presentations
Cross reactive antibody clones from 10x genomics BEAM experiment displayed on Phylogenetic tree dendrogram on PipeBio Bioinformatics antibody sequence analysis platform. Dendrogram includes antigen specificity, score based on detected liabilities and CDRH3 sequence of antibody clone.