You can define and identify sequence-based liabilities and automatically flag sequence motifs when annotating sequences on PipeBio
Post-translational modifications cause additional sequence variation and alter the antibody binding properties. This might be troublesome when developing antibodies designed against a specific target.
Inaccurate annotation of sequences or detection of liabilities and identification of mutations will lead to decreased efficacy of promising lead candidates. Efficient and exact annotation tools are therfore needed to ensure the developability.
PTMs include the addition of functional groups in the amino acid chain, the modification of existing amino acids in the sequence or the cleavage of bonds, among others [3, 4].
Below is a list of liabilities detected by the default IgG scaffold on PipeBio: